Uncovering the Bone-Muscle Interaction and Its Implications for the Health and Function of Older Adults (the Wellderly Project): Protocol for a Randomized Controlled Crossover Trial

Background Bone and muscle are closely linked anatomically, biochemically, metabolically. Acute exercise affects both bone muscle, implying a crosstalk between the two systems. However, how these systems communicate is still largely unknown. We will explore role of undercarboxylated osteocalcin (ucOC) in this crosstalk. ucOC involved glucose metabolism has potential maintenance metabolism. Objective The proposed trial determine if circulating levels older adults at baseline following acute associated with parameters function response to varies low quality those normal or high quality. Methods A total 54 men women aged 60 years no history diabetes warfarin vitamin K use be recruited. Screening tests performed, including for functional, anthropometric, clinical presentation. On basis quality, combined equation lean mass (leg appendicular skeletal kg) strength press; one-repetition maximum), participants stratified into group randomized controlled crossover intervention. Three visits performed approximately 7 days apart, aerobic exercise, resistance control session (rest) completed any order. Our primary outcome study effect on function. Results active ongoing. Recruitment began February 2018, 38 have as May 26, 2019. Conclusions This provide novel insights adults, potentially identifying new biomarkers mechanistic targets drug treatments sarcopenia other related musculoskeletal conditions. Trial Registration Australia New Zealand Clinical Trials Registry ACTRN12618001756213; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=375925. International Registered Report Identifier (IRRID) DERR1-10.2196/18777